Botulinum toxin is prescribed in order to treat certain disorders related to eye such as crossed eyes and uncontrolled blinking, for the treatment of muscle spasms or movement disorders (cervical dystonia, torticollis), and in order to reduce the cosmetic appearance of wrinkles. It is also prescribed in order to prevent headaches in patients with frequent migraines. Botulinum toxin is effective in relaxing muscles by blocking acetylcholine.
This medication is also recommended to treat overactive bladder by patients who do not respond to or cannot tolerate the adverse reactions of other drugs. It is effective in reducing the leaking of urine, frequent trips to the bathroom and feeling of needing to urinate right away. It is also recommended to treat excess saliva and severe underarm sweating. Botulinum toxin acts by blocking the chemicals that turn on the sweat and salivary glands. Precautions:
Warnings:
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Ibrutinib specifically is a cell signal blocker that targets a protein named 'Bruton’s tyrosine kinase’ (BTK). BTK is a part of a pathway that helps B cells in order to stay alive as well as divide. Blocking BTK can make B cells die or prevent them from dividing. This treatment acts by stopping the spread of cancerous B cells.
Ibrutinib is recommended to be given as tablets that should be taken orally (by mouth). The recommended dose is based on the type of lymphoma you have and your health status. Always follow the words of your healthcare provider when consuming ibrutinib 140 mg. Precautions:
Warnings:
What is anastrozole?
Anastrozole is a medication indicated to treat women breast cancer who have gone through the menopause. Specifically this drug is used for the hormone receptor-positive breast cancer. Arimidex is the brand name of Anastrozole. It is believed that men with breast cancer may be given this drug, although tamoxifen is the most commonly recommended drug. How does anastrozole 1 mg work? This drug works by reducing the oestrogen made in the body. Some breast cancers are stimulated in order to grow by the hormone oestrogen, which are called oestrogen receptor positive or ER+ breast cancers. Prior to menopause, oestrogen is produced in the ovaries. Following menopause, the ovaries does not produce oestrogen, but some oestrogen is made in body fat. This process involves an enzyme known as aromatase. The anastrozole 1 mg is the aromatase inhibitor group of drugs. These inhibitors block the aromatase enzyme from working. It leads to less oestrogen in the body in order to help breast cancer cells to grow. Side effects of anastrozole: Like any medicine, anastrozole may leave side effects. Everyone reacts in different ways to medications and some people have more adverse reactions than others. Having few or no adverse reactions doesn’t mean that the medication isn’t effective. The common anastrozole side effects include:
When is anastrozole given? This medication is usually recommended to be given after surgery in order to reduce the risk of breast cancer from coming back or spreading. If you’re having chemo or radiotherapy, your doctor will let you know when it’s best to start anastrozole. From time to time, the anastrozole used as the first treatment for breast cancer, for instance when surgery isn’t an option or needs to be delayed. It’s sometimes recommended prior to surgery in order to shrink a large sized breast cancer. The anastrozole are also applicable in order to treat recurrence breast cancer. It may also be given for treating breast cancer that has spread to other organs of the body, when it’s often given together with other drugs. Recommended Dosage: The recommended dose of Anastrozole is one 1 mg tablet, should be taken once daily. For those patients who are with advanced breast cancer, anastrozole needs to be continued until tumor progression. No dosage adjustment is crucial for the patients with the renal impairment or for the patients who are elder. How is anastrozole taken? This drug should be given as a tablet once daily, either with or without food. It would be best if you take anastrozole tablets at the same time each day. If you forget a dose, you must avoid taking double doses. The drug level in your body will remain high enough from the day before. How long will I have to take anastrozole? This will depend on your individual circumstances. Anastrozole is usually taken for 5 to 10 years. Some patients start taking anastrozole after a number of years of taking another hormone therapy drug called tamoxifen. If you’re on anastrozole 1 mg in order to treat recurrence breast cancer or that has spread to other organs of the body, you’ll continue it till it is keeping your cancer controlled. If you’re taking anastrozole 1 mg tablet in order to reduce the risk of breast cancer developing because of your family history, you’ll usually take it for 5 years. Warning & Precautions:
Do not take anastrozole 1 mg tablet if you:
Taking anastrozole with other drugs: If you’re with any other prescribed or over-the-counter medications, interact with your healthcare team if you can take these with anastrozole dosage. Avoid taking other drugs containing oestrogen, such as hormone replacement therapy (HRT), while you’re on with anastrozole as this may interfere with its effectiveness. Discuss with your GP about any additional therapies, herbal remedies or supplements you want to use prior to start using them. How Should I Store Anastrozole: Store this medication at 68°F to 77°F (20°C to 25°C). Keep the arimidex and all medicines out of the reach of children. Where can I find Anastrozole (Arimidex) at the best price? In India, the anastrozole price is quite reasonable. Prices may vary from branded to non-branded (generic) drugs. Any WHO-GDP & ISO certified pharmaceutical wholesaler company would be appropriate in order to get anastrozole at a best price. FAQ's From which family of drugs Anastrozole belongs? Anastrozole specifically falls under the aromatase inhibiting family of drugs. Does Anastrozole may cause weight gain? Yes, this medication may be responsible for causing weight gain, but it is uncommon. There could be certain other reasons, which may lead to weight gain such as menopause. Can Anastrozole Tablet be taken at night? Anastrozole tablets can be taken anytime of the day. But it is recommended to take your tablets exactly as instructed by your healthcare practitioner. You may take these tablets either with or without food. Avoid chewing, crushing, or breaking the anastrozole tablet. Does Anastrozole 1mg cause hair loss? Yes, anastrozole tablets commonly affect hairs by making them thin, leading to hair loss. In what circumstances should I call my doctor, while on Anastrozole? Patients should call their doctor in case they have any serious adverse reaction. It is crucial to report to a doctor in case of prolonged or severe nausea or vomiting, extreme pain and extreme weakness. What is the storage condition for Anastrozole? Store anastrozole at 20 to 25°C. It should be stored in the airtight container. NOTE: The piece of information mentioned about "ALL ABOUT ANASTROZOLE" in this article is just for the informational purposes and is not served as a substitute for medical treatment, consultation, diagnosis of a qualified doctor. Regorafenib is a prescription medication used in order to treat people with Metastatic colorectal cancer, Advanced hepatocellular carcinoma, Advanced gastrointestinal stromal tumours.
This medication is not recommended in order to treat children who are less than 18 years of age. Recommended Dose: The recommended usual dose of regorafenib is 160 mg (four regorafenib 40 mg tablets). The treatment should be continued until disease progression or unacceptable toxicity. How should regorafenib be given: This drug is taken exactly as your doctor instructs you. The tablets should be swallowed whole. It must be taken at the same time every day with the low-fat breakfast. Regorafenib usually should be given 1 time a day for 3 weeks and then stop for 1 week. This is basically 1 cycle of treatment. This cycle of treatment should be repeated for as long as your healthcare professional team tells you to. Adverse Reactions: The most commonly reported regorafenib side effects are as follows:
Warning & Precautions:
What should I avoid while on regorafenib? It is recommended that patients should avoid drinking grapefruit juice and taking St. John’s Wort while on stivarga treatment. These may affect the way this medication works. Missed Dose: If you forget or miss any dose, take it as soon as you remember on that day. Avoid taking double doses on the same day in order to make up for a forgotten or missed dose. Overdose: If you consume too much regorafenib call your healthcare professional or go to the nearest hospital right away. How do I store Regorafenib: Regorafenib tablets should be stored at room temperature between 68°F to 77°F (20° C to 25° C). Keep regorafenib 40 mg in the bottle that it comes in. Keep the bottle of Stivarga tightly closed. Do not put the tablets in a daily or weekly pill box. What is the cost of regorafenib? In India, the regorafenib price (brand Nublexa, containing 28 tablets in 1 strip) is around Rs 54294. It is recommended to buy this drug from WHO-GDP & ISO certified pharmaceutical wholesaler company. Conclusion: Regorafenib demonstrated in order to increase the overall survival of patients with metastatic colorectal cancer. The drug has shown an anti-angiogenic activity because of its dual targeted VEGFR2-TIE2 TKI (tyrosine kinase inhibition). Classified as a first-generation antihistamine, Promethazine is prescribed for treating allergies, sleep troubles, and nausea. In fact, it is also proven to help in dealing with some of the symptoms of common cold and allergy, such as itching and rash. Promethazine is used as a sedative for patients with anxiety or agitation. The medicine is available in four distinct forms: oral tablets, oral solution, rectal suppository, and injectable solution.
Promethazine- Dosage and Usage The drug blocks histamine, which is a particular natural substance in the body produced during allergies. Other than that, it can also block the action of acetylcholine by affecting certain parts of the brain. The medicine comes in various dosage strengths such as Promethazine 25mg, 50mg, and 12.5mg. Take it in the exact same dosage which the doctor has recommended. The average dosage is Promethazine 25mg each day, but it can vary according to different conditions. Usually, the oral tablets are taken 2 to 4 times a day with or without food.
Remember that the particular dosage for Promethazine is based on your age, weight, medical condition, and medical history. It is not the same for everyone, even if they have developed the same condition. Precautionary Measures for Promethazine
The product must not be given to children who are less than 6 years. The long-acting Phenergan 25mg tablets and capsules are not suitable for children below 12 years. Elderly patients must start with the lowest dose to avoid risks. Remember that the medicine will not shorten the length of the common cold or cure it permanently; it will simply treat the symptoms. Side Effects of Promethazine These are some of the common side effects of Promethazine:
If you are feeling restless or confused, getting frequent mood swings and hallucinations, talk to your doctor about it, especially if the symptoms are persisting for a long. Final Words Promethazine has been approved by the FDA, but at present, only the generic versions are available in the US. According to a medical study conducted on children, its efficacy was established successfully in 43% of the test subjects. The clinical effects are seen to last 4 to 6 hours maximum. Remember that patients can also overdose on this and develop critical conditions such as breathing troubles, which may prove to be fatal. In such a case, emergency medical attention is mandatory. The medicine must not be suddenly discontinued without getting approval from your doctor. Sofosbuvir (SOF) specifically is a NS5B polymerase inhibitor recommended as the backbone of the different DAAs regimens. The drug is quite well tolerated causing some adverse reactions, such as nausea, fatigue, insomnia, headache, anemia, pruritus and dizziness, that basically occur more frequently when it is used together with the ribavirin (RBV). The several drug interactions of sofosbuvir tablets 400 mg are as follows:
Note: Inform your healthcare professional about all the medications you take, including vitamins, prescription, over-the-counter medications and herbal supplements. Other medications may affect how sofosbuvir works. One bottle cost of originator Sovaldi 400 mg containing 28 Tablets is around 23571 INR. You may get the lower sofosbuvir price if you choose to buy an Indian generic rather than originator brand. Indication: Zoledronic acid is a bisphosphonate class drug used in the treatment of hyperglycemia (high blood calcium level) and multiple myeloma. The drug is also used along with chemotherapy for the treatment of different types of bone problems caused due to cancer and multiple myeloma.
Functioning of drug: The metastatic cancer cells reach to the bone and produce certain substances that dissolve the osteoclast present in the bone. This causes the weakening of bone. As zoledronic acid is a bisphosphonate it slows down the dissolution of osteoclast. The zoledronic acid uses help in order to prevent the bone fractures and decrease the complications. Dosage: This drug is available in an injection form that is injected intravenously, no oral pill form is available. Different concentrations of the injections are 4 mg/100 mL, 4 mg/5 mL available in a single-use vial. The zoledronic acid dose depends upon the general health of the patient, type of cancer, health problems, and the condition being treated. Drug interactions:
Side Effects: Some common side effect of zoledronic acid include:
Storage: The vial is stored at 2°C – 8°C. Use the vial immediately after opening, if the solution is not used immediately stored the vial in the refrigerator and should be used before 24 hours of a seal breaking. Do not freeze the inj zoledronic acid. Price: The zoledronic acid price is very reasonable and affordable. This drug is generally available at all registered pharmaceutical companies, the patient can either buy the medication from an offline drug store or by placing an order on any company's official website. Humira is a Tumor Necrosis Factor (TNF) blocker. It is recommended for used in order to reduce the signs and symptoms of:
The drug humira 40 mg should be administered by subcutaneous injection. This drug should be received in the dose as well as duration as recommended by your healthcare provider. Some serious infections have occurred in people taking this drug. Serious infections are TB (tuberculosis) and infections which are basically caused by the fungi, viruses or bacteria that have spread throughout the body. Humira shouldn't be taken if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. Remember, inform your healthcare provider right away if you experience an infection or symptoms of an infection. You should discuss the potential benefits as well as risks of humira with your healthcare provider. This is a TNF blocker that may lower the ability of your immune system in order to fight infections. HUMIRA should be stored in the refrigerator between 36°F to 46°F (2°C to 8°C). Store it in the original carton until used to protect it from light. The humira price may vary from innovator branded drugs to generic versions. You must hold a valid prescription prior to purchasing it. For women, the state of relapse of the Ovarian Cancer after going through proper treatment like first-line chemotherapy or surgery is termed as recurrence. It must be mentioned here that it can recur anywhere, but the most common area is the abdominal cavity. If you come across any of these symptoms like abdominal pain, nausea, bloating, vomiting, etc., consult your doctor immediately to start treatment. According to medical studies and reports, the five-year survival rate for ovarian cancer is 47%. Researchers claim that around 70% of the total number of cases will have a chance of relapsing. The patients who have been diagnosed in the earliest stage (Stage 1) have about a 10% chance of recurrence.
Palbociclib—A breakthrough in the treatment of recurrent ovarian cancer There is not much that can help to treat recurrent metastatic ovarian cancer effectively. Recently, Ibrance Palbociclib has been approved to treat this condition in patients who have previously undergone cytotoxic chemotherapy and hormone therapy. It is a cyclin-dependent kinase inhibitor that blocks the action of CDK4 and CDK6 on the cancer cells and curbs their growth. Dosage The usual dosage, in this case, is palbociclib 125 mg. Depending on your medical condition and extent of the disease, your doctor may alter the amount. It is available in capsule form that needs to be taken each day at the same time, within 30 minutes of having a meal. Usually, the patient takes one capsule in 3 weeks. Precautionary Methods
Although the toxicity profile of Palbociclib is relatively moderate, there may be certain side effects that the patient needs to be aware of:
If you have a fever with chills (body temperature of 100.4 F or above), consider it a medical emergency. For patients with estrogen receptor-positive locally advanced ovarian cancer, the combination of Palbociclib and Letrozole has managed to record a good response in controlling the disease. It interferes with the growth of tumor cells by blocking the enzymes that promote cancer-cell growth. Treatments associated with recurrent ovarian cancer It depends a lot on the type of treatment that you've received in the past, whether the recurrence will be high-risk or not. In case the disease has relapsed within six months or lesser, alternative chemotherapy is opted by doctors because it is classified then as a platinum-resistant condition. Some women also participate in clinical trials to get the first-hand benefits of investigational drugs. If it is a platinum-sensitive case, i.e., if the disease has relapsed after more than 6 months, the usual treatment is to be carried on with a platinum-based drug and another type of chemotherapy agent. Medication used in treating ovarian and recurrent ovarian cancer Other than Ibrance 125 mg, there are several other drugs for the treatment of ovarian and recurrent ovarian cancer. Mention may be made of the following here:
Apart from the afore-mention medications FDA has approved a few more such as Bevacizumab, Cyclophosphamide, Lynparza (Olaparib), Zejula (Niraparib Tosylate Monohydrate), Hycamtin (Topotecan Hydrochloride), Doxil (Doxorubicin Hydrochloride Liposome), etc for the treatment of recurrent ovarian cancer. Combination Therapy Drugs for Ovarian Cancer The various combination drugs used for treating primary and recurrent ovarian cancers are BEP, Carboplatin-Taxol, Gemcitabine-Cisplatin, VAC, PEB, and many more. When the body does not respond well to one chemotherapy agent, combination therapy can be helpful. Conclusion The progression-free survival of ovarian cancer saw a significant improvement from treatment with Palbociclib. It can also be taken with hormone therapies or an aromatase inhibitor (depending on the type of cancer). Palbociclib price is relatively high in the market, around $13006 for a total of 21 capsules. You can contact Indian Pharma to get the best prices. Read:- Types of Breast cancer Well-known as Actinomycin D in the pharmaceutical world, Dactinomycin is an antineoplastic chemotherapy drug used for the treatment of Wilms' tumor, ovarian cancer, metastatic testicular tumors, Gestational trophoblastic neoplasm, Ewing's sarcoma, childhood Rhabdomyosarcoma, soft tissues sarcoma, and Osteosarcoma. It has been classified as an antitumor antibiotic that aims at destroying the DNA of the cancer cells so that it cannot divide, and further growth is stopped.
Dactinomycin Uses and Dosage Firstly, it is given in combination with other anti-cancer drugs like Vincristine, Actinomycin D, Cyclophosphamide, and Ifosfamide. Dactinomycin injection is given intravenously as a drip into the bloodstream. A small tube or a cannula is placed into one of the veins that help connect the drip. Since Dactinomycin 0.5 mg is a vesicant drug, it can severely damage the tissues that come in direct contact with it. That is why it is mandatory to get it from a trained professional at all times. Usually, it takes around 10-15 minutes for infusion. This drug therapy is conducted in cycles, and the dosage varies depending on the type of cancer, your health condition, body weight, medical history, etc. The cycles last from 8 weeks to 112 weeks, based on the type of condition that is being treated and the response from the body. It is typically administered once every 3 weeks for most conditions. Precautionary Measures While receiving Dactinomycin injection, go through the following precautionary measures to stay safe:
Side Effects of Dactinomycin 0.5mg
Dactinomycin's side effects are entirely predictable and manageable. Sometimes they are dependent on the other treatments that you are receiving currently like radiation therapy. They easily go away once the therapy is stopped. Note that early treatment will definitely help you to cope with the side effects better. If you have a very high fever with a body temperature of 37.5 degrees C or more, contact your healthcare professional immediately. Commonly Asked Questions: 1. What are the uses of Actinomycin? The actinomycin uses are as follows:
Yes, Actinomycin D is a chemotherapy medication. 3. Is Dactinomycin an antibiotic? Dactinomycin specifically is an intravenously administered, antineoplastic antibiotic drug, used for the treatment of solid tumors in children and choriocarcinoma in adult women. 4. How do you take Actinomycin D? Actinomycin D is taken by injection into a vein. 5. How does actinomycin D work? Actinomycin D is a polypeptide antibiotic isolated from the genus Streptomyces. This drug intercalates into DNA, preventing the RNA polymerase's progression. It is widely considered as a transcription inhibitor. Conclusion Before starting therapy, your doctor will conduct a thorough medical checkup to determine whether your condition is suitable for it. The medicine also alters your WBC count. Routine checkups will be conducted to monitor your disease progression and health conditions. The cost of Dactinomycin 0.5 mg injection is around $1234. The overall survival rate in patients who have received this drug is 100% (disaster-free success rate). Read:- About Eribulin Mesylate |
AuthorMy Name is Amit Sharma I am a pharmacist, I am having 25+ years of experience in Pharma medications. ArchivesCategories
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